regime (n.)

c. 1400, medical, "course of diet, exercise, etc. for sake of health; regulation of such matters as influence health," mid-15c., "act of governing," from Old French regimen (14c.) and directly from Latin regimen "rule, guidance, government, means of guidance, rudder," from regere "to rule, to direct, keep straight, guide" (from PIE root *reg- "move in a straight line," with derivatives meaning "to direct in a straight line," thus "to lead, rule").

By 1751 in the transferred sense of "any regulation or remedy intended to produce gradual, beneficial effects." Regimen, regime, and, later, regiment (n.), all from the same Latin verb, were not always clearly distinguished in English, and as recently as late 19c. each of the first two was used even by careful writers in senses now restricted to the other. 

1794, from French ancien régime, literally "old rule," referring to the government and social order of France before the Revolution there. See ancient + regime.

Proto-Indo-European root meaning "move in a straight line," with derivatives meaning "to direct in a straight line," thus "to lead, rule."

It forms all or part of: abrogate; address; adroit; Alaric; alert; anorectic; anorexia; arrogant; arrogate; bishopric; correct; corvee; derecho; derogate; derogatory; Dietrich; direct; dress; eldritch; erect; ergo; Eric; Frederick; Henry; incorrigible; interregnum; interrogate; maharajah; Maratha; prerogative; prorogue; rack (n.1) "frame with bars;" rail (n.1) "horizontal bar passing from one post or support to another;" Raj; rajah; rake (n.1) "toothed tool for drawing or scraping things together;" rake (n.2) "debauchee; idle, dissolute person;" rakish; rank (adj.) "corrupt, loathsome, foul;" real (n.) "small Spanish silver coin;" realm; reck; reckless; reckon; rectangle; rectify; rectilinear; rectitude; recto; recto-; rector; rectum; regal; regent; regicide; regime; regimen; regiment; region; regular; regulate; Regulus; Reich; reign; resurgent; rex; rich; right; Risorgimento; rogation; royal; rule; sord; source; subrogate; subrogation; surge; surrogate; viceroy.

It is the hypothetical source of/evidence for its existence is provided by:

Sanskrit raj- "a king, a leader," rjyati "he stretches himself," riag "torture" (by racking); Avestan razeyeiti "directs," raštva- "directed, arranged, straight;" Persian rahst "right, correct;" Latin regere "to rule, direct, lead, govern," rex (genitive regis) "king," rectus "right, correct;" Greek oregein "to reach, extend;" Old Irish ri, Gaelic righ "a king," Gaulish -rix "a king" (in personal names, such as Vircingetorix), Old Irish rigim "to stretch out;" Gothic reiks "a leader," raihts "straight, right;" Lithuanian raižytis "to stretch oneself;" Old English rice "kingdom," -ric "king," rice "rich, powerful," riht "correct;" Gothic raihts, Old High German recht, Old Swedish reht, Old Norse rettr "correct."