"biological pocket or receptacle," 1741, from French sac, from Latin saccus "bag" (see sack (n.1)). English sack for "a sack-like part of the body" is from mid-14c.

also Sacajawea, name of the Shoshoni woman who accompanied and aided the Lewis & Clark expedition.

She had been a captive among the Hidatsas (a Siouan people), and her Hidatsa name was tsaka'aka wi'a, lit. 'bird woman' (Hartley, 2002). Her Shoshoni name, rendered as Sacajawea and translated 'boat launcher,' may have been a folk-etymological transformation of the Hidatsa term (Shaul, 1972). [Bright]

Her image appeared on U.S. dollar coins from 2000.

"a violent check of a horse by giving a sudden pull on the reins," 1705, from French saccade "a jerk," from obsolete saquer "to shake, pull," a dialectal variant of Old French sachier, which is perhaps ultimately from Latin saccus "sack" (see sack (n.1)). Related: Saccadic.

white crystalline compound, odorless but intensely sweet, used as a sugar substitute, 1885, from German, coined 1879 by Russian-born chemist Constantin Fahlberg (1850-1910), who discovered it by accident, from Latin saccharon (see saccharine); for ending see -in (2). Marketed from 1887 as saccharine.

1670s, "of or like sugar, having the qualities of sugar," from Medieval Latin saccharum "sugar," from Latin saccharon "sugar," from Greek sakkharon, from Pali sakkhara, from Sanskrit sarkara "gravel, grit" (see sugar). The metaphoric sense of "overly sweet" is recorded by 1841. For the sugar substitute, see saccharin. Related: Saccharinity.

"of or belonging to priests or the priesthood," c. 1400, from Old French sacerdotal and directly from Latin sacerdotalis "of or pertaining to a priest," from sacerdos (genitive sacerdotis) "priest," literally "offerer of sacrifices or sacred gifts," from sacer "holy" (see sacred) + stem of dare "to give" (from PIE root *do- "to give"). Related: Sacerdotalism "methods of priests; devotion to the interests of priests," in 19c. often in a bad sense, "priestcraft."

chief of a Native American tribe, 1620s, from Narragansett (Algonquian) sachim "chief, ruler," cognate with Abenaki sangman, Delaware sakima, Micmac sakumow, Penobscot sagumo. Applied in jocular use to a prominent member of any society from 1680s; specific political use in U.S. is by 1890, from its use in New York City as the title of the 12 high officials of the Tammany Society.

1838, "small bag, usually embroidered or otherwise ornamented, containing perfume powder, etc., placed among articles of dress," from French sachet, literally "little sack" (12c.), a diminutive of sac (see sac). A reborrowing of a word that Middle English had used in the sense "small bag, wallet" (15c., saket).

"sherry," 1530s, an alteration of French (vin) sec "dry (wine)," from Latin siccus "dry" (see siccative). Originally of strong, light-colored wine from Spain and the Canaries. OED notes that the vowel is "not a normal development from the original 'seck.' "

"plunder; act of plundering, the plundering of a city or town after storming and capture," 1540s, from French sac "pillage, plunder," from or identical with Italian sacco (see sack (v.1)).