the later Romans evidently found words beginning in sc-, sp-, st- difficult or unpleasant to pronounce; in Late Latin forms begin to emerge in i- (such as ispatium, ispiritu), and from 5c. this shifted to e-. The development was carried into the Romanic languages, especially Old French, and the French words were modified further after 15c. by natural loss of -s- (the suppression being marked by an acute accent on the e-), while in other cases the word was formally corrected back to the Latin spelling (for example spécial). Hence French état for Old French estat for Latin status, etc. It also affected Romanic borrowings from Germanic (such as espy, eschew).
A different e- is a reduced form of Latin ex- before consonants (see ex-), and the e- in enough is an unfelt survival of an Old English alternative form of ge-.
word-forming element referring to the environment and man's relation to it, abstracted from ecology, ecological; attested from 1969.
word-forming element generally meaning "outside, external," before vowels ect-, from Latinized form of Greek adverb ektos "outside, out of; free from; exempt" (opposed to entos), used to form compounds in Greek (such as ektomē "a cutting out"); related to Greek ek, ex "out," from PIE *eghs "out" (see ex-).
word-forming element used for "vagina" in medical terms, from Greek elytron, literally "sheath" (see elytra). Related: Elytral.
word-forming element meaning "put in or into, bring to a certain state," sometimes intensive, from French assimilation of en- "in, into" (see en- (1)) to following labial stop (-b-, -p-, and often -m-), or from the same development in later Latin in- (to im-). "This rule was not fully established in spelling before the 17th c." [OED], but it is likely the pronunciation shift was in Old French and Middle English and spelling was slow to conform. Also a living prefix in English used to form verbs from adjectives and nouns (embitter, embody). In words such as emancipate, emerge, emit, emotion the e- is a reduced form of Latin ex- (see ex-) before -m-.
word-forming element in pathology meaning "condition of the blood," Modern Latin combining form of Greek haima (genitive haimatos) "blood," a word of no established etymology (replacing the usual IE word, represented in Greek by ear; possibly from uncertain PIE root *sei- "to drip" (compare Old High German seim "virgin honey," Welsh hufen), but according to Beekes this proposal "cannot explain the Greek vocalism."
word-forming element meaning "in; into," from French and Old French en-, from Latin in- "in, into" (from PIE root *en "in"). Typically assimilated before -p-, -b-, -m-, -l-, and -r-. Latin in- became en- in French, Spanish, Portuguese, but remained in- in Italian.
Also used with native and imported elements to form verbs from nouns and adjectives, with a sense "put in or on" (encircle), also "cause to be, make into" (endear), and used as an intensive (enclose). Spelling variants in French that were brought over into Middle English account for parallels such as ensure/insure, and most en- words in English had at one time or another a variant in in-, and vice versa.
word-forming element meaning "inside, within, internal," from Greek endon "in, within" (from PIE *en-do-, extended form of root *en "in").
