symptom (n.)

"a departure from normal function or form as an expression or evidence of a disease," late 14c., sinthoma, from Medieval Latin sinthoma "symptom of a disease," altered from Late Latin symptoma, from Greek symptoma "a happening, accident, disease," from stem of sympiptein "to befall, happen; coincide, fall together," from assimilated form of syn- "together" (see syn-) + piptein "to fall" (from PIE *pi-pt-, reduplicated form of root *pet- "to rush; to fly").

The spelling was re-Latinized from c. 1540, perhaps in part by influence of French symptome (16c.). The general (non-medical) use, "any sign or indication of the existence of something else," is from 1610s.